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1. | | SOUZA, M. M. de; ZERLOTINI NETO, A.; GEISTLINGER, L.; TIZIOTO, P. C.; TAYLOR, J. F.; ROCHA, M. I. P.; DINIZ, W. J. S.; COUTINHO, L. L.; REGITANO, L. C. de A. A comprehensive manually-curated compendium of bovine transcription factors. Scientific Reports, v. 8, p. 1-12, 2018. Article number: 13747. Na publicação: Adhemar Zerlotini, Luciana C. A. Regitano. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Registros recuperados : 1 | |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Corte. Para informações adicionais entre em contato com cnpgc.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Gado de Corte. |
Data corrente: |
17/07/2018 |
Data da última atualização: |
27/09/2018 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
B - 1 |
Autoria: |
ANDREOTTI, R.; GIACHETTO, P. F.; CUNHA, R. C. |
Afiliação: |
RENATO ANDREOTTI E SILVA, CNPGC; POLIANA FERNANDA GIACHETTO, CNPTIA; RODRIGO CASQUERO CUNHA, Bolsista PNPD/Capes. |
Título: |
Advances in tick vaccinology in Brazil: from gene expression to immunoprotection. |
Ano de publicação: |
2018 |
Fonte/Imprenta: |
Frontiers in Bioscience - Scholar, v. 10, n. 1, p. 127-142, Jan. 2018 |
Idioma: |
Inglês |
Conteúdo: |
Rhipicephalus (Boophilus) microplus has substantial economic impact on the cattle breeding industry and, chemical control and tick resistance development are the major concern. There is a worldwide search for new options, and control using vaccines has been the main focus nowadays. Studies performed in Brazil found that Bm86-based immunization of bovines reduced the infestation of R. (B.) microplus of vaccinated bovines by 45% to 60%. Native Boophilus microplus tripsin inhibitors (BmTIs) with trypsin-, kallikrein-, and elastase-inhibiting activities have been used as immunogens in bovines reaching 72.8.% of efficacy. The reverse vaccinology approach has also been used for antigen search using transcriptome analysis to identify and characterize potential antigens. Study has generated more than 600 million sequences using RNA-seq of larvae, nymphs, salivary glands, intestines, and ovaries of the tick R. (B) microplus. Based on the set of transcripts obtained using this strategy, a total of 20,326 protein sequences have been identified. A pipeline analysis built in house identified the protein sequences that were most likely to be immunogenic based on the overall structural characteristic analysis. |
Thesagro: |
Vacina. |
Thesaurus NAL: |
Gene expression; Rhipicephalus microplus; Transcriptome; Vaccines. |
Categoria do assunto: |
-- X Pesquisa, Tecnologia e Engenharia |
Marc: |
LEADER 01823naa a2200205 a 4500 001 2093371 005 2018-09-27 008 2018 bl uuuu u00u1 u #d 100 1 $aANDREOTTI, R. 245 $aAdvances in tick vaccinology in Brazil$bfrom gene expression to immunoprotection.$h[electronic resource] 260 $c2018 520 $aRhipicephalus (Boophilus) microplus has substantial economic impact on the cattle breeding industry and, chemical control and tick resistance development are the major concern. There is a worldwide search for new options, and control using vaccines has been the main focus nowadays. Studies performed in Brazil found that Bm86-based immunization of bovines reduced the infestation of R. (B.) microplus of vaccinated bovines by 45% to 60%. Native Boophilus microplus tripsin inhibitors (BmTIs) with trypsin-, kallikrein-, and elastase-inhibiting activities have been used as immunogens in bovines reaching 72.8.% of efficacy. The reverse vaccinology approach has also been used for antigen search using transcriptome analysis to identify and characterize potential antigens. Study has generated more than 600 million sequences using RNA-seq of larvae, nymphs, salivary glands, intestines, and ovaries of the tick R. (B) microplus. Based on the set of transcripts obtained using this strategy, a total of 20,326 protein sequences have been identified. A pipeline analysis built in house identified the protein sequences that were most likely to be immunogenic based on the overall structural characteristic analysis. 650 $aGene expression 650 $aRhipicephalus microplus 650 $aTranscriptome 650 $aVaccines 650 $aVacina 700 1 $aGIACHETTO, P. F. 700 1 $aCUNHA, R. C. 773 $tFrontiers in Bioscience - Scholar$gv. 10, n. 1, p. 127-142, Jan. 2018
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Embrapa Gado de Corte (CNPGC) |
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